Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH.

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Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH

Lysosomes labeled by uptake of extracellular horseradish peroxidase display remarkable changes in shape and cellular distribution when cytoplasmic pH is experimentally altered. Normally, lysosomes in macrophages and fibroblasts cluster around the cell center. However, when the cytoplasmic pH is lowered to approximately pH 6.5 by applying acetate or by various other means, lysosomes promptly mov...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 1989

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.108.3.855